Bioinformatic studies of the effect of <i>Curcumin glucuronide</i> in the plants of the <i>Curcuma longa</i> species on DNA gyrase inhibition as antimicrobial agent
Bioinformatic studies of the effect of Curcumin glucuronide in the plants of the Curcuma longa species on DNA gyrase inhibition as antimicrobial agent

Farideh Ebrahimi؛ Fatemeh Sholehvar؛ Azizeh Asadzadeh

دوره 7، اول ، شهریور 1400، ، صفحه 30-37

https://doi.org/10.30470/jmpb.2021.251029

چکیده
  DNA gyrase is an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA. DNA gyrase has long been known as an attractive target for antibacterial drugs. Curcumin is a polyphenol, found in the spice turmeric, that has promising anticancer and antimicrobial properties. The aim of this research is ...  بیشتر
Computational molecular docking simulation study of Kojic acid glucoside as antibacterial agents
Computational molecular docking simulation study of Kojic acid glucoside as antibacterial agents

Omid Ali Behzadi؛ Azizeh Asadzadeh

دوره 7، اول ، شهریور 1400، ، صفحه 38-43

https://doi.org/10.30470/jmpb.2021.251030

چکیده
  Kojic acid is a fungal metabolic product produced by a few species of Aspergillus, especially by A. oryzae, which has the Japanese common name koji. This compound is an inhibitor of growth of bacteria and multiplication of viruses. In this study, kojic acid derivative, Kojic acid glucoside, was evaluated as DNA gyrase activity inhibitors. DNA gyrase has ...  بیشتر